We argue that the long-shared history of port and city has led to the emergence of a connective port city culture that has facilitated the understanding between port and city actors as well as citizens. We propose that such a port city culture can also serve as a tool to facilitate spatial planning, and to improve how port, city and regional authorities take shared responsibilities in addressing infrastructural and mobility questions, and to develop common perspectives on the energy transition, or new work and living conditions. With the growth of the port over multiple cities and municipalities and the extension of its infrastructure into the hinterland, the connection between the port city culture and space will have to be restored. Port cities have the potential to mobilize talent from a high concentration of people which could be a tremendous source of competitive advantage for companies in the time-driven economy in this day and age We argue that the concept of creative capital and creative cities is yet to be adapted to the concept of port city region relations. The concept of the port city culture is also emphasized in the 2030 agenda of AIVP, which sees it as a way to conceptually and spatially connect interfaces between the port and its urban and other surroundings.